Biggest change so far: It's been a total career change and I've had to adjust my perspective significantly. The State Department encourages intellectual independence -- the Foreign Service truly places a high value on constructive dissent -- but in the end, my job entails defending and supporting the policies of the United States 24/7.
Am I sleeping better? Well, I no longer worry about getting laid off. Gaining or losing weight? I'm on a government per-diem now and the restaurants around here are pretty decent. I'll just leave it at that. I've also had to learn to be diplomatic in and out of work. F-bombs and extreme cynicism aren't as common in my new work place.